Why Should IV Calcium Be Given Slowly?

How does calcium gluconate stabilize the heart?

Calcium antagonizes the cardiotoxicity of hyperkalemia by stabilizing the cardiac cell membrane against undesirable depolarization.

Onset of effect is rapid (≤ 15 minutes) but relatively short-lived..

How does calcium affect the heart?

Calcium particles enter the heart muscle cells during each heartbeat and contribute to the electrical signal that coordinates the heart’s function. Calcium particles also bind to machinery within the cell that helps the cell to squeeze together (“contract”), which makes the heart pump blood.

Why would you need a calcium infusion?

Calcium gluconate is the calcium salt of gluconic acid, an intravenous medication used to treat conditions arising from calcium deficiencies such as hypocalcemic tetany, hypocalcemia related to hypoparathyrodism, and hypocalcemia due to rapid growth or pregnancy.

What is the antidote for calcium gluconate?

Sodium thiosulfate and hyaluronidase prevent the development of calcium deposits after calcium gluconate extravasation.

Why Calcium gluconate is given after blood transfusion?

The potential for hypocalcemia among patients receiving large amounts of donated blood products over a short time period is due to the presence of the anticoagulant citrate in the bag that donated blood is collected to. Each unit of packed red cells for transfusion contains approximately 3 gm citrate.

Why is calcium gluconate used in labor and delivery?

Your urine output will also probably be measured every hour in the hospital to avoid toxicity. If for some reason the levels get too high, another medication, called calcium gluconate, can help reverse the effects of magnesium sulfate.

Why Calcium gluconate is given slowly?

To avoid undesirable reactions that may follow rapid intravenous administration of calcium gluconate, the drug should be given slowly, e.g., approximately 1.5 mL over a period of one minute.

What does calcium gluconate do to the heart?

Rapid intravenous injections of calcium gluconate may cause hypercalcaemia, which can result in vasodilation, cardiac arrhythmias, decreased blood pressure, and bradycardia. Extravasation of calcium gluconate can lead to cellulitis. Intramuscular injections may lead to local necrosis and abscess formation.

What are the benefits of calcium gluconate?

It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).

Can calcium gluconate be mixed with normal saline?

To avoid adverse reactions that may follow rapid intravenous administration, Calcium Gluconate Injection should be diluted with 5% dextrose or normal saline and infused slowly.

What is the antidote for magnesium sulfate?

Calcium gluconate: the antidote for magnesium toxicity is calcium gluconate 1 g IV over 3 minutes. Repeat doses may be necessary. Calcium chloride can also be used in lieu of calcium gluconate.

What can you do for low calcium levels?

Treatment. Calcium supplements, given by mouth, are often all that is needed to treat hypocalcemia. If a cause is identified, treating the disorder causing hypocalcemia or changing drugs may restore the calcium level. Once symptoms appear, calcium is usually given intravenously.

How fast can you give Calcium Gluconate IV?

Generally, infuse a bolus dose over 30 to 60 minutes. Calcium gluconate may be administered at a rate not exceeding 200 mg/minute. In general, inject IV 10% calcium gluconate products slowly, at a rate of 1.5 mL/minute (150 mg/minute) or less to avoid adverse reactions.

How long does a calcium infusion take?

Approximately 100 to 200 mg of elemental calcium (in case of calcium gluconate: 93 mg elemental calcium in 1 gram of calcium gluconate) should be infused over a period of 10 minutes to treat symptomatic hypocalcemia.

What is IV calcium gluconate used for?

Calcium gluconate is the calcium salt of gluconic acid, an intravenous medication used to treat conditions arising from calcium deficiencies such as hypocalcemic tetany, hypocalcemia related to hypoparathyrodism, and hypocalcemia due to rapid growth or pregnancy.